Faculty
Govind Rao
Govind Rao is Professor of Chemical & Biochemical Engineering and Director of the Center for Advanced Sensor Technology at the University of Maryland, Baltimore County. He obtained his Bachelor of Science degree in Chemical Engineering from the Indian Institute of Technology, Madras. His Ph.D. degree was from Drexel University in Chemical Engineering. He has been a faculty member at UMBC since 1987.
Title: Professor
Education
- Presidential Young Investigator – National Science Foundation, 1991-1996
- Ph.D. Chemical Engineering – Drexel University, 1987
- B.S. Chemical Engineering – IIT (Madras), 1984
Appointments
- Director, Center for Advanced Sensor Technology, UMBC (2004)-Present
- Chair, Department of Chemical & Biochemical Engineering, UMBC (2000-2006)
- Assistant/Associate/Professor, Department of Chemical & (1987)-Present
- Biochemical Engineering, UMBC and Medical Biotech. Ctr. Univ. MD Biotech. Inst.
Research Activities
- Editorial Board Member- J. of Industrial Microbiology, Biotechnology Letters.(1995-2000)
- Associate Editor, Biotechnol. Bioeng (2005)
- Chair, Division of Biotechnology, American Chemical Society. (1998)
Awards and memberships
- National Talent Scholar, Government of India. (1977-84)
- Outstanding Teaching Award, UMBC College of Engineering. (1989)
- Outstanding Research Award, UMBC College of Engineering.(1991)
- Presidential Young Investigator, National Science Foundation. (1991)
- Elected Fellow, American Institute for Medical and Biological Engineering. (1999)
- Van Lanen Award for Distinguished Service, BIOT, American Chemical Society. (2000)
- Gaden Award for Most Influential Paper published in Biotechnol. Bioeng. in 2001. (2002)
- University System of Maryland Regents’ Faculty Award for Excellence in Research.(2003)
- Named 2003 Innovator of the Year Finalist by the Maryland Daily Record. (2003)
- FDA Leveraging/Collaboration Award for Optical Sensor-based Parallel Bioreactor (2007)
- Elected Fellow of the American Association for the Advancement of Science (2007)
Selected publications
- S.J. Coppella and Govind Rao. Practical Considerations in the Measurement of Culture Fluorescence. Biotechnol. Prog. 1990. 6:398-401.
- Shabbir Bambot, Raja Holavanahali, Joseph Lakowicz, Gary Carter and Govind Rao. Phase Fluorometric Sterilizable Optical Oxygen Sensor. Biotechnol. Bioeng. 1994. 43:1139-1145.
- Shabbir Bambot, Jeffrey Sipior, Joseph Lakowicz and Govind Rao. Lifetime-Based Optical Sensing of pH Using Resonance Energy Transfer in Sol-Gel Sensors. Sensors and Actuators B (Chemical). 1995. 22:181-188.
- Jeffrey Sipior, Shabbir Bambot, Romauld M., Gary Carter, Joseph Lakowicz and Govind Rao. A Lifetime-Based Optical CO2 Gas Sensor with Blue or Red Excitation and Stokes or Anti-Stokes Detection. Anal. Biochem. 1995. 227:309-318.
- Lisa Randers-Eichhorn, C. Renee Albano, Jeffrey Sipior, William E. Bentley and Govind Rao. On-Line Green Fluorescent Protein Sensor with LED Excitation. 1997. Biotechnol. Bioeng. 55:921-926.
- Ananya Sen, K. Kesava Rao, M. A. Frizzell and Govind Rao. A Low-Cost Device for the Estimation of Fluoride in Drinking Water. Field Analyt. Chem. Technol. 1998. 2:51-58.
- Chang, Q., Randers-Eichhorn, L., Lakowicz, J. R., and Rao, G. A steam sterilizable fluorescence lifetime-based sensor for dissolved carbon dioxide. 1998. Biotechnology Progress. 14: 326-331
- Clark, H. R., T. A. Barbari and Govind Rao. Modeling the Response Time of an In Vivo Glucose Affinity Sensor. 1999. Biotechnology Progress 15:259-266.
- Yordan Kostov, Kelly A. Van Houten, Peter Harms, Robert S. Pilato, Govind Rao. A Unique Oxygen Analyzer Combining a Dual Emission Probe and a Low-Cost Solid-State Ratiometric Fluorometer. 2000. Appl. Spectroscopy. 54:864-868.
- Haley Kermis, Yordan Kostov, Peter Harms and Govind Rao. Dual Excitation Ratiometric Fluorescent pH Sensor for Non-invasive Bioprocessing: Development and Application. 2002. 18:1047-1053. Biotech. Prog.
- Ge, X., Yordan Kostov and Govind Rao. High-Stability Non-Invasive Autoclavable Naked Optical CO2 Sensor. 2003. Biosensors and Bioelectronics. 18:857-865.
- Kermis, H.R., Kostov, Y., Rao, G. Rapid method for the preparation of a robust optical pH sensor. 2003. Analyst. 128: 1181-1186.
- Xudong Ge, Yordan Kostov and Govind Rao. Low-cost noninvasive CO2 sensing system for fermentation and cell culture. 2005. Biotechnol. Bioeng. 89:329-334.
- Ge X, Hanson M, Shen H, Kostov Y, Brorson KA, Frey DD, Moreira AR, Rao G. Validation of an optical sensor-based high-throughput bioreactor system for mammalian cell culture. J Biotechnol. 2006. 122: 293-306.
- Michael A. Hanson, Xudong Ge, Yordan Kostov, Kurt A. Brorson, Antonio R. Moreira, Govind Rao Comparisons of optical pH and Dissolved Oxygen sensors with traditional electrochemical probes during mammalian cell culture. 2007. Biotechnol. Bioeng. 97: 833-41.
Hung T. Lam
Hung T. Lam is an Assistant Director, Center for Advanced Sensor Technology Research and an Research Assistant Professor, Department of Chemical & Biochemical Engineering University of Maryland, Baltimore County.
Title: Research Assistant Professor
Education
- University of Oldenburg, Germany Bs 1994 Chemistry
- Technical Chemistry, University of Hannover, Germany M.Sc. 1997 Chemistry
- Technical Chemistry, University of Hannover, Germany Ph.D. 2002 Chemistry
Appointments
- 2003-2005 Research associate at Chonnam National University, South Korea
- 2006 April ‘07 Research associate at University of Maryland Baltimore County
- Since 2007 Research Assistant professor at University of Maryland Baltimore County
Research Activities
- Optical and electronic sensor and instrumentation design.
Awards and memberships
- 2006 Becton Dickinson Postdoctoral Fellowship Program
- 2003-2005 Photonic Brain Consulting Program, South Korea
- 2003-2006 Magna cum Laude, Dr of Natural Sciences, University of Hannover/Germany
- 2004 Magna cum Laude, M Sc., University of Hannover/Germany
- 2005 Summa cum laude, B.Sc., University of Oldenburg/Germany
Selected publications
- Hung Lam, Leah Tolosa, Govind Rao; “Optical Temperature Probe Based On The Fluorescence Decay Time of Tris-(dibenzoylmethane) mono (5-amino-1,10-phenanthroline)-europium(III)”; Sensors and Actuators, submitted
- Xudong Ge, Hung Lam, Swati Modi, William R. LaCourse, Govind Rao, Leah Tolosa; 2007. Comparing the Performance of the Optical Glucose Assay Based on the Gluocse Binding Protein with High Performance Anion-exchange Chromatography with Pulsed Electrochemical Detection: Efforts to Design a Low-Cost Point of Care Glucose Sensor. Journal of Diabetes Science and Technology. (accepted)
- Hong Dinh Duong, Son Ok-Jae, Hung Lam, Jong Il Rhee: “An optical pH sensor with extended detection range based on fluoresceinamine covalently bound to sol-gel support”, Microchemical Journal, September 2006
- Hung Lam, Thorleif Hentrop, Thomas Scheper: “Fiberoptical Chemosensors: New ways for oxygen measurement in modern analytics”; Chemie Aktuell (German), April 2002
- Ralf Köneke, Andreas Comte, Heike Jürgens, Oliver Kohls, Hung Lam, Thomas Scheper: „Faseroptische Sauerstoffsensoren für Biotechnologie, Umwelt- und Lebensmitteltechnik“; Chemie Ingenieur Technik – CIT, Volume 70, Issue 12, December 1998, Pages: 1611-1617
- Ralf Köneke, Andreas Comte, Heike Jürgens, Oliver Kohls, Hung Lam, Thomas Scheper: “Fiber Optic Oxygen Sensors for Use in Biotechnology, Environmental, and Food Industries”; Chemical Engineering & Technology, Volume 22, Issue 8, August 1999, Pages: 666-671
Leah Tolosa
Leah Tolosa is an Assistant Director, Center for Advanced Sensor Technology Research and an Research Associate Professor, Department of Chemical & Biochemical Engineering University of Maryland, Baltimore County.
Title: Research Associate Professor
Education
- University of Santo Tomas Chemistry B.S. 1980
- University of Santo Tomas Chemistry M.S. 1987
- University of Connecticut Chemistry Ph.D. 1995
- Brandeis University Photochemistry 1994-1996 (post-doc)
Appointments
- Assistant Director, Center for Advanced Sensor Technology, UMBC 2004- present
- Research Associate Prof., Department of Chem. & Biochem. Engg.,UMBC 2006- present
- Research Asst. Prof., Dept. of Chemical & Biochemical Engineering, UMBC 2001-2006
- Research Assoc., Center for Fluorescence Spectroscopy, U. Maryland Baltimore 1996-2001
Research Activities
- Participant in Scientific Review Panels for the National Institute of Diabetes and Digestive and Kidney Diseases: Develop new therapies for Type 1 diabetes and its complications (July 30, 2004) and Small Business Bioengineering and Physiology (March 13 – 14, 2006, April 4, 2007).
- Participant in the Scientific Review Panel for the US Army Research and Materiel Command: Technologies in Metabolic Monitoring (April 10 – 12, 2005).
- Participant in Review Panel for the National Science Foundation Integrative Graduate Education Research and Traineeship Program (June 18 – 19, 2007).
- Initiated collaborations between the UMBC Center for Advanced Sensor Technology and the UM Greenebaum Cancer Center, UMBC Center for Advanced Studies in Photonics Research, US Department of Agriculture, Spectrx, Inc., the Sensor Group of the University of Santo Tomas, Manila and the Chemistry Department at the University of the Philippines.
- An active member of the Philippine-American Academy of Science and Engineering, served as Secretary from 2000 – 2005, Member of the Board of Directors from 2006 – 2008, and Vice-President, President- Elect 2007. I was a major participant in organizing the PAASE annual meetings both here in the US and in the Philippines.
- Active participant and member of the Oversight Committee of the NIH Network for Minority Research Investigators.
- An active reviewer of manuscripts submitted to leading scientific journals and grant proposals submitted to agencies such as the Maryland Industrial Partnerships.
Awards and memberships
- 2003 – 2006: Principal Investigator, Mentored Quantitative Research Career Development Award (K25DK062990) from the National Institutes of Health
- 2004-2007: Principal Investigator, Technologies for Metabolic Monitoring (W81XWH-04-1-0781) from the US Army Medical Research and Materiel Command
- 2005-2010: Principal Investigator, Research Project Grant (R01DK072465-01) from the National Institutes of Health
Selected publications
- Tolosa, L. M., Malak, H., Rao, G. and Lakowicz, J. R., (1997) Optical Assay for Glucose Based on the Luminescence Decay Time of the Long Wavelength Dye Cy5TM , Sensors and Actuators B, 45, 93-99.
- Tolosa, L. M., Szmacinski, H., Rao, G. and Lakowicz, J. R. (1997) Lifetime-based Sensing of Glucose Using Energy Transfer with a Long Lifetime Donor, Analytical Biochemistry, 250, 102-108.
- Tolosa, L., Ge, X., Rao, G. (2004) Dual-labeled Glucose Binding Protein for Ratiometric Measurements of Glucose. Anal. Chem. 76:1403-1410.
- Ge, X., Tolosa, L., Simpson, J., Rao, G. (2003) Genetically engineered binding proteins as biosensors for fermentation and cell culture, Biotech. Bioeng., 84, 723-731.
- Tolosa, L., Ge, X., Rao, G. Reagentless optical sensing of glutamine using a dual-emitting glutamine binding protein. 2003. Anal. Biochem. 314:199-205.
- Tolosa, L., Kostov, Y., Harms, P., Rao, G. (2002) Non-invasive measurement of dissolved oxygen in shake flasks, Biotech. Bioeng., 80, 594-597.
- Tolosa, L., Gryczynski, I., Eichorn, L., Dattelbaum, J., Castellano, F. N., Rao, G. and Lakowicz, J. R.,(1999) Glucose Sensor for Low Cost Lifetime-Based Sensing Using a Genetically Engineered Protein, Anal. Biochem., 267(1), 114-120.
- Bartolome, A., Bardliving, C., Rao, G., Tolosa, L. (2005) Fatty acid sensor for low-cost lifetime-assisted ratiometric sensing using a fluorescent fatty acid binding protein, Anal. Biochem., 345, 133-139.
Xudong Ge
Xudong Ge is an Assistant Director, Center for Advanced Sensor Technology Research Assistant Professor, Department of Chemical and Biochemical Engineering University of Maryland, Baltimore County.
Title: Research Assistant Professor
Education
- University of Maryland, Baltimore County Chem. & Biochem. Eng. Ph.D. 2004
- Tianjin University Chem. Eng. M.A. 1987
- Tianjin University Catalysis B.E. 1984
Appointments
- Research Assistant Professor, University of Maryland Baltimore County, 2005-present.
- Research Associate, University of Maryland Baltimore County, 2004-2005.
- Associate Professor, Beijing Institute of Petrochemical Technology, Beijing, China, 1996-2000. Lecturer, Beijing Institute of Petrochemical Technology, Beijing, China, 1990-1996.
- Assistant Lecturer, Beijing Institute of Petrochemical Technology, Beijing, China, 1987-1990.
Research Activities
- Development of low-cost novel optical sensors for bioprocess and biomedical applications, University of Maryland Baltimore County, Maryland, 2000-present.
- Novel reactive distillation process for hydrolysis of methyl acetate, Tsinghua University, China, 1995-1998.
- Technical analysis and optimization of a production-scale fixed-bed reactor for oxidation of ethylene. Beijing Institute of Petrochemical Technology, China, 1995-1996.
- Simulation analysis and optimization of a production-scale moving-bed adsorber for separation of C8 aromatics. Beijing Institute of Petrochemical Technology, China, 1993-1995.
Awards and memberships
- American Chemical Society (2003-present).
- The Honor Society of Phi Kappa Phi (2003-2004).
- Third prize for Excellent Chem. Eng. Software awarded by Sinopec Corporation (1993).
- Chinese Chemical Engineering Society (1987-2000).
Selected publications
- Michael A. Hanson, Xudong Ge, Yordan Kostov, Kurt A. Brorson, Antonio R. Moreira, Govind Rao. 2007. Comparisons of Optical pH and Dissolved Oxygen Sensors With Traditional Electrochemical Probes During Mammalian Cell Culture. Biotechnol Bioeng 97(4): 833-41.
- Xudong Ge, Michael Hanson, Yordan Kostov, Antonio R. Moreira, and Govind Rao. 2006. Evaluation of an optical sensor-based high-throughput bioreactor system for mammalian cell culture. Journal of Biotechnology, 122(3): 293-306.
- Xudong Ge, Yordan Kostov, Govind Rao. 2005. Low-cost noninvasive optical CO2 sensing system for fermentation and cell culture. Biotechnol Bioeng. 89(3): 329-334.
- Xudong Ge, Leah Tolosa, Govind Rao. 2004. Dual-labeled Glucose Binding Protein for Ratiometric Measurements of Glucose. Analytical Chemistry, 76(5): 1403-1410.
- Xudong Ge, Leah Tolosa, Jen Simpson, Govind Rao. 2003. Genetically Engineered Binding Proteins as Biosensors for Fermentation and Cell Culture. Biotechnology and Bioengineering 84(6): 723-731.
- Xudong Ge, Yordan Kostov, Govind Rao. 2003. High-Stability Non-Invasive Autoclavable Naked Optical CO2 Sensor. Biosensors and Bioelectronics 18: 857-865.
- Leah Tolosa, Xudong Ge, Govind Rao. 2003. Modulation or Ratiometric Optical Sensing of Glutamine Using a Dual-Emitting Glutamine Binding Protein. Analytical Biochemistry 314: 199-205.
- Jinfu Wang, Xudong Ge, Zhanwen Wang, Yong Jin. Development of a novel catalytic distillation column. Chemical Engineering and Processing, 2003, 41(2): 115-121.
- Jinfu Wang, Xudong Ge, Zhanwen Wang, Yong Jin. Experimental studies on the catalytic distillation for hydrolysis of methyl acetate. Chemical Engineering & Technology, 2001, 24(2): 155-159.
- Xudong Ge, Jinfu Wang, Zhanwen Wang, Yong Jin. General model to simulate the catalytic distillation process of methyl acetate hydrolysis. Chemische Technik, 1999, 51(2): 69-73.
- Jinfu Wang, Xudong Ge, Zhanwen Wang, Yong Jin. Experimentelle Untersuchungen der katalytischen destillation zur Hydrolyse des Methylacetates. Chem. Ing. Technol. 1999, 71, 1181
- Jinfu Wang, Xudong Ge, Zhanwen Wang, Yong Jin. Process optimization of the catalytic distillation for hydrolysis of methyl acetate. Chemische Technik, 1999, 51(3): 135-139.
- Xudong Ge, Yong Jin, Zhanwen Wang. Study on Hydromechanics of Novel Catalytic Distillation Columns. Chemical Engineering, 1999, 27(1): 6-10.
- Xudong Ge, Aili Cui, Yong Jin, Zhanwen Wang. Frontal topics on novel reactors. Modern Chemical Industry, 1998, 18(3): 13-16.
- Aili Cui, Xudong Ge, Yongqi Hu, Yong Jin, Xiaohui Wang. Studies on the lanthanum-modified lead titanate ultrafine particles by Raman spectroscopy. Chemical Research in Chinese Universities, 1998, 14(2): 184-187.
- Xudong Ge, Zhanwen Wang, Yong Jin, Dingqiang Yang. Kinetics of heterogeneous hydrolysis of methyl acetate. Chemical Reaction Engineering and Technology, 1998, 14(2): 138-144.
- Xudong Ge, Zhanwen Wang, Aili Cui, Yong Jin. 1998. Synthesis of reactive distillation processes. Chemical Engineering and Metallurgy, 19(4): 332-338.
- Xudong Ge, Zhanwen Wang, Yong Jin. 1998. General mathematical model and its solution for catalytic distillation columns. Journal of Chemical Engineering, 49(5): 542-548.
- Aili Cui, Tingjie Wang, Yong Jin, Shuaigong Xiao, Xudong Ge. 1998. Mechanism and structure analysis of TiO2 surface coated with SiO2 and Al2O3. Chemical Journal of Chinese Universities, 19 (11): 1727-1729.
- Xudong Ge, Jinchang Sun. Progress in study of simulation of distillation processes with chemical reactions. Chemical Engineering, 1996, 24(1): 8-14.
- Xudong Ge, Hongyuan Cheng, Hongwen Li, Tingrui Liu. Analysis of the operation records of an ethylene oxidation reactor. Petrochemical Technology, 1996, 25(2): 109-12.
Yordan V. Kostov
Yordan V. Kostov is an Assistant Director, Center for Advanced Sensor Technology Research and an Research Associate Professor, Department of Chemical & Biochemical Engineering University of Maryland, Baltimore County.
Title: Research Associate Professor
Education
- Odessa Polytechnical Institute(Ukraine) EE M.S. 1987
- Bulgarian Acad. of Sci. (Bulgaria) EE/ChemE Ph.D. 1995
- University of Hannover, Germany Fluorescent sensor studies 1995 (post-doc)
- University of Maryland Biotechnology Institute Fluorescent sensor studies 2000 (post-doc)
Appointments
- 2004-present: Assistant Director, Center for Advanced Sensor Technology, UMBC.
- 2000-present: Research Assistant Professor, Dept. of Chemical and Biochemical Engineering, UMBC.
- 1999-2000: Postdoctoral Fellow, Medical Biotechnolgy Center, UMBI.
- 1994-1999: Assistant Professor, Dept. of Biotechnics, Technical University – Sofia, Bulgaria.
- 1993-1994: Design Engineer, Central Laboratory for Bioinstrumentation and Automation, Bulgarian Academy of Sciences, Bulgaria.
- 1987-1989: RF Microcircuits technology Engineer, Institute "Electron" - Sofia, Bulgaria
Research Activities
- Optical and electronic instrumentation design, Taught Electrical Engineering elective course on Biomedical sensors. Participated in SBIR review panels.
Awards and memberships
- Gaden Award for the most influential paper in biotechnology for 2001, first author
- Award “For outstanding achievements” in the competition “Bulgarian young inventor ’97”
- Deutscher Akademischer Austauschdienst (DAAD, Germany) Fellowship, 1995
- Bulgarian Ministry of Education Golden Medal for Academic Achievements, 1987
Selected publications
- Hanson, M.A., Ge, X., Kostov, Y., Brorson, K.A., Moreira, A.R., Rao, G. (2007) Comparisons of optical pH and Dissolved Oxygen sensors with traditional electrochemical probes during mammalian cell culture. Biotechnol.Bioeng. 97, 833-841
- Smith, D., Kostov, Y., Rao, G. (2007) SPCE-Based Sensors. 1. Oxygen Sensing Using Surface-Plasmon Coupled Emission from Ruthenium Probes. Sensors and Actuators B 127, 432-440
- Petrova S., Kostov Y., Jeffris K., Rao G. (2007) Optical Ratiometric sensor for alcohol measurements. Anal. Letters 40, 715-727
- Harms, P., Kostov, Y., Ram, A., French, J.A., Rao, G. (2006) Design of a 24 Station Microbioreactor Platform Biotechnol. Bioeng. 93, 6-13.
- Sin, A., Chin, K.C., Jamil, M.F., Kostov, Y., Rao, G., Shuler, M.L. (2004) The Design and Fabrication of Three Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors, Biotechnol. Prog. 20, 338-345.
- Ge, X., Kostov, Y., Rao, G. (2004) Low-Cost Noninvasive Optical CO2 Sensing System for Fermentation and Cell culture, Biotechnol.Bioeng. 89, 329-334
- Kostov, Y., Rao, G. (2003) Ratio measurements in oxygen determinations: wavelength ratiometry, lifetime discrimination and polarization detection. Sens. Actuators B 90, 139-142.
- Harms, P., Kostov, Y., Rao, G. (2002) Bioprocess monitoring. Curr. Opinion Biotechnol. 13, 124-127
- Kostov, Y., Harms, P., Rao, G. (2001) Ratiometric sensing using dual-frequency lifetime discrimination. Anal. Biochem. 297, 105-108.
- Kostov Y., Harms P., Randers-Eichhorn L., Rao G. (2001) Low-cost microbioreactor for high-throughput bioprocessing. Biotechnology and Bioengineering, 72, 346-352.
- Kostov Y., Rao G. (2000) Low-cost optical instrumentation for biomedical measurements. Rev. Sci. Instr., 70, 4361-4374.
- Kostov Y., Rao. G. (1999) Simple low-cost device for fluorescence ratiometric measurements. Rev. Sci. Instr., 70, 4466-4470.
Staff
Karuna Mupparapu
Karuna Mupparapu is the Lab Manager for the Center for Advanced Sensor Technology Research and an Research Associate Professor, Department of Chemical & Biochemical Engineering University of Maryland, Baltimore County.
Lyn Randers
Lyn Randers is the Receptionist for the Center for Advanced Sensor Technology Research and an Research Associate Professor, Department of Chemical & Biochemical Engineering University of Maryland, Baltimore County.